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The Ryan Lab investigates how pathogenic mitochondrial DNA mutations influence innate immune function, inflammatory responses, cellular metabolism, and susceptibility to infection. The lab uses primary macrophage models, mouse models of mitochondrial disease, immunological assays, metabolic phenotyping, molecular biology, and multi-omics approaches to understand how inherited mitochondrial defects reshape innate immune signalling and inflammatory disease susceptibility.
This postdoctoral role will focus on defining how pathogenic mitochondrial DNA mutations alter macrophage function, innate immune signalling, type I interferon responses, inflammatory cytokine production, cellular metabolism, and responses to inflammatory or infectious stimuli. The postholder will work with ex vivo primary macrophage systems derived from mitochondrial disease models and will integrate wet-lab immunology, mitochondrial biology, molecular biology, metabolism, and in vivo-linked sample workflows.
The role would suit a motivated postdoctoral researcher with experience in immunology, mitochondrial biology, metabolism, infection biology, inflammatory disease, molecular biology, or a related area, who is seeking to develop an independent research profile within mitochondrial immunometabolism.
Application Procedure
Applicants should submit a full Curriculum Vitae plus a short cover letter to include the names and contact details of 2 referees (including email addresses), to:-
Dr. Dylan Ryan
Please use the subject line: Postdoctoral Research Fellow Application – Ryan Lab.
The cover letter should briefly outline the candidate’s relevant research experience, interest in the research area, motivation for applying, and how their expertise aligns with the role.
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