Purpose
The Enterprise Productivity Office (EPO) Lead is a strategic partner to the Alexion Leadership Team (ALT), and functional leaders, identifying and shaping opportunities to improve organizational effectiveness, productivity, and enterprise performance. Leading a lean, agile team, this role diagnoses business challenges, builds business cases, advances AI/digital and operating model opportunities, and enables functions to adopt scalable solutions that simplify work, increase capacity, and improve delivery across Alexion.
Key Accountabilities
- Enterprise effectiveness and productivity strategy: Partner with executive and functional leaders to identify opportunities to improve organizational effectiveness, decision speed, productivity, operating models, location strategy, and ways of working.
- Executive advisory and business case development: Diagnose business challenges, develop actionable recommendations, quantify value and investment requirements, and influence prioritization, resourcing, and CEO/ALT decision-making.
- AI, digital and data enablement: Identify and advance opportunities to leverage AI, automation, digital tools, and data-driven capabilities to improve efficiency, effectiveness, and employee experience.
- Organizational transformation and change: Lead work involving operating model evolution, functional effectiveness, shared services/global business services approaches, workforce productivity, and sustainable adoption of new ways of working.
- Enterprise capability building: Create scalable tools, frameworks, dashboards, playbooks, and repeatable approaches that enable functions to independently drive continuous improvement and measurable impact.
Scope and Interfaces
- Stakeholders: EPO SteerCo, Alexion CEO, ALT members, global functional leaders, HR, Finance, Digital & IT, enterprise partners, and external advisors/vendors as needed.
- Team: Direct leadership of a lean EPO team, including project management and finance business partnering resources.
- Primary users: Alexion and AstraZeneca Rare Disease functions seeking to simplify work, improve effectiveness, increase capacity, and accelerate delivery.
Core Deliverables
- Productivity strategy and opportunity pipeline: Maintain a prioritized, enterprise-wide pipeline of high-value productivity and transformation opportunities.
- Executive-ready business cases: Develop clear recommendations covering value, investment, risks, organizational implications, implementation options, and decision requirements.
- AI/digital and operating model solutions: Partner across functions to identify, test, and scale solutions that improve productivity and effectiveness.
- Adoption and value realization: Define success measures and track outcomes against baseline, including cost, capacity, cycle-time, quality, employee experience, and adoption metrics.
Role distinction: This is not primarily a large project portfolio or traditional PMO role. Success requires influencing senior leaders, shaping strategy, building business cases, and driving organizational change through a lean, agile team.
Qualifications
- 10+ years in enterprise transformation, management consulting, business operations, organizational effectiveness, strategy, digital transformation, AI enablement, or related leadership roles.
- Proven ability to partner with executive teams, diagnose ambiguous business challenges, shape solutions, and influence strategic decisions without direct authority.
- Demonstrated experience developing business cases that drive enterprise value and measurable outcomes.
- Experience with operating model redesign, organizational transformation, workforce productivity, location strategy, functional effectiveness, or business process excellence.
- Experience identifying and implementing AI, digital, automation, or data-driven capabilities that improve organizational effectiveness.
- Exceptional executive communication, stakeholder management, analytical, synthesis, and problem-solving skills.
- Advanced degree in business, life sciences, engineering, data science, organizational effectiveness, or a related field preferred.
Success Profile
The successful candidate is a strategic, influential leader who thrives in ambiguity and demonstrates exceptional agility—adapting quickly to shifting priorities, evolving business landscapes, and emerging challenges with resilience and composure. They move seamlessly from diagnosing complex business problems to shaping executive recommendations, building compelling business cases, and enabling adoption, pivoting with confidence when conditions change. They combine organizational effectiveness, transformation, change leadership, AI/digital acumen, and executive influence with a resilient mindset that sustains momentum through uncertainty, creating scalable solutions and measurable enterprise impact.
Why Join Alexion Enterprise Productivity Office?
The EPO enables Alexion’s 2030 Bold Ambition by driving productivity, innovation, organizational effectiveness, and operational excellence. In this role, you will work directly with senior leaders on high-visibility opportunities, advance AI/digital and operating model improvements, and build scalable approaches that help functions simplify work, increase capacity, and improve delivery.
Travel
Travel to key hubs and sites as required.
Date Posted
05-Aug-2026
Closing Date
18-Aug-2026
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
